Do you know what the main role of cycloserine is?
Cycloserine Cs is a scientific name for D--4-amino-3-tetrahydroisoxazolone. Molecular formula C3H6N2O2, molecular weight 102. 09. This product has a broad-spectrum antibacterial effect, inhibits most Gram-positive and Gram-negative bacteria, but has a weak antibacterial effect, and has a good inhibitory effect on Mycobacterium tuberculosis. Its system of action is to inhibit and affect microbial cell wall. Synthesis. Cycloserine has a good inhibitory effect on Mycobacterium tuberculosis. Because bacteria are not easy to develop resistance, it is primarily used for the treatment of drug-resistant Mycobacterium tuberculosis infection. Additionally , D-cycloserine is a special regulator of excitatory amino NMDA receptors in the central nervous system, and it also has a good adjuvant effect on the treatment of mental phobia, depressive disorder, schizophrenia and other psychological diseases. It is usually an important intermediate for the activity of atypical β-lactam antibiotic Lactivicin.
Can you know what the key role of cycloserine is?
Cycloserine has been the key drug for replicating radiation treatment before the creation of RFP. Cycloserine itself is not easy to produce drug resistance, it is usually effective against drug-resistant hetiquez, and it can also prevent bacteria from being resistant to propyl isoxanthamide (Pto). One of the key drugs for the treatment of multidrug-Resistant Hetiquez (MDR-TB), but the household oral preparation of cycloserine has been lacking. Lately, MDR-TB is increasing everyday. The first-line drugs of isoniazid and rifampic are often unable to meet the needs of clinical treatment. The low resistance rate of cycloserine to tuberculosis is valued. The Planet Health Organization recommends the use of cycloserine for the treatment of MDR- T. Therefore, D-cycloserine has broad application prospects and huge market demand.
[Physical and chemical properties]
Cycloserine is a white or light yellow crystalline powder, which is hygroscopic, odorless and slightly bitter. Resoluble in water, soluble in ethanol, slightly soluble in chloroform, ether. The 10% aqueous solution has a pH of 5. seven to 6. 3. That is stable when the pH of the aqueous solution is 6-8.
[indications]
Cycloserine is clinically used for drug-resistant Mycobacterium tisis to cause infection. This is often employed in combination with other anti-tuberculosis drugs such as isoniazid, streptomycin and p-aminosalicylic acid, and may also be used for urinary : tract infection caused by Escherichia coli.
[Pharmacological action and mechanism of action]
Cycloserine is a second-line anti-tuberculosis drug. The antibacterial spectrum is broad, and possesses inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, but their effect is weaker than streptomycin and isoniazid. Their antibacterial mechanism is to interfere with the activity of bacterial cell surfaces. The concentration of anti-tuberculosis bacteria is 5-20 mg/L. No cross-resistance to anti-tuberculosis drugs. This product will not be easy to produce drug level of resistance.
【Pharmacokinetics】
Oral absorption of cycloserine is rapid, and the peak plasma concentration is reached after oral management for 3 to 4 hours. Oral administration of 0. 25g peaked at an average of 4mg/L, repeated medication, can reach a higher peak. The plasma half-life is 12 hours. After absorption, it is distributed in complete body tissues and body fluids, and can dissipate into the fetal circulation and cerebrospinal fluid, ascites, and milk. A lot of them are excreted by the kidneys in the original form, and those with reniforme insufficiency are prone to accumulate poisoning, and a small amount is discharged from the feces.
【medicine interactions】
1, taking ethionamide at the same time can raise the neurotoxicity of this product.
2, alcohol and this product have incompatibility, specially when taking this product in big amounts, alcohol can improve the opportunity and risk of seizures.
3, the program of this product and isoniazid can boost the incidence of central nervous system toxicity, such as fatigue or lethargy. The dose to be administered must be adjusted and key nervous system toxicity should be closely monitored.
【Adverse reactions】
1. Mainly for the nervous system toxic response, can cause mental misunderstandings, depression, behavioral changes, and sometimes sudden suicide, so if there is personality change and excessive depressive disorder, it ought to be discontinued and firmly guarded.
2. Patients with original epilepsy or emotional illness are hanged.
