What are the effects of taking metamizole?
First, the side effects of metamizole drugs
In the antipyretic family, metamizole has the most effective fever, nevertheless the most adverse reactions are also dangerous. The worth of metamizole cannot be denied. Metamizole is a mixture of aminopyrine and sodium sulfite. It was used as an antipyretic analgesic in the twenties. However, since the 1980s, it has been basically no extended used clinically. Metazizzole has been banned in 35 countries across the world, not to mention the United States, Japan, Australia, and even poor countries such as Nepal and Nigeria. However, the effect of our country is that metamizole is still in production, small clinics and pharmacies remain selling, and dangerous adverse reaction cases occur frequently.
metamizole
Metamizole side outcomes
Some people have metamizole in their homes. This is not scientific to take them with severe headaches and fever. Metamizole is mainly used for antipyretic fever during high fever. It can even be used for headache, pain, dysmenorrhea, etc., but it is generally not used because the first choice. Only in the case of acute high fever, severe illness, and no other effective antipyretic drugs are available. Can be used for unexpected emergency heat removal.
Metamizole has been available for many years, and the efficacy of headaches for fever is very obvious. There are many people in countryside areas. The long-term use of metamizole is very opposed. As it happens that long-term use of metamizole can lead to a decrease in granulocytes in the individual blood. In severe situations, granulocytosis can occur, displaying symptoms of fatigue and general malaise. If metamizole eats more, it will eventually cause dependence. Be careful with metamizole.
Because metamizole has its own side effects, such as allergies, collapse, leukopenia, reniforme dysfunction, etc., serious can cause drug-induced aplastic anemia, acute hematopoietic stagnation. In this article, if there are symptoms such as fever and headache, it is best not to take metamizole easily. You can use other antipyretic and analgesic drugs instead. When necessary, it is highly recommended to come to the clinic in time.
Second, metamizole and which drugs will appear
1. The chance of bleeding when the drug is along with acenocoumarol, anthraquinone, dicoumarin, benzodiazepine, warfarin, eptifibatide, danaparone, low molecular weight heparin increase.
2. When combined with calcium channel blockers, the risk of gastrointestinal bleeding boosts.
3. When combined with alendronate, the stimulating impact on the gastrointestinal tract is increased, so extreme caution should be exercised when used together.
4. Once the drug is combined with ketorolac, the gastrointestinal aspect effects increase, and there may be digestive ulcers, gastrointestinal bleeding and/or perforation.
5. This medicine can improve the risk of cyclosporine poisoning. When used together, renal dysfunction, cholestasis, and paresthesia may occur.
six. This drug can reduce the clearance rate of methotrexate, ultimately causing methotrexate poisoning, leukopenia, thrombocytopenia, anemia, toxic renal damage, mucosal ulcer formation and other adverse reactions.
7. When used in mixture with li (symbol), the clearance rate of lithium is lowered, and the plasma concentration is increased, which may cause associated with lithium poisoning.
8. Once the drug is mixed with ofloxacin and levofloxacin, it can inhibit the action of gamma-aminobutyric acid solution, thereby increasing the chance of seizures.
9. Phentermine can interfere with the production of prostaglandins, so that the angiotensin-converting enzyme inhibitor, β-adrenergic blocker antihypertensive effect and natriuretic result are reduced.
10. Any time coupled with loop diuretics and thiazide diuretics, the diuretic and antihypertensive effects of diuretics are reduced.
10. When coupled with potassium-sparing diuretics, the latter's diuretic result is reduced, hyperkalemia may occur, and toxic renal damage could also occur.
13. When employed in combo with sulfonylureas, the metabolism of sulfonylureas is inhibited and the risk of hypoglycemia increases.
Third, the impact of taking metamizole
Although the drug is less irritating to the stomach tract, it can cause various adverse reactions the following:
1. Hematology: can cause neutropenia, the incidence rate is about 1. 1%, showing acute onset, and severe cases are dangerous. Additionally, it may cause immune hemolytic anemia, thrombocytopenic purpura and aplastic anemia.
2. Epidermis: It could cause allergic manifestations such as urticaria, medicine eruption, and exudative erythema. In severe cases, exfoliative dermatitis and bullous epidermolysis can occur, and even dying can happen.
3. Local responses: redness and pain may occur at the injection site, and it will subside after a day or two. High-dose intramuscular injection can cause severe large-scale aseptic necrosis in the injection, triggering toxemia and even death.
4. In some cases, anaphylactic shock may occur after administration of the drug, and even death may result.
5. In the case of intramuscular injection, some patients could have sweating, chest firmness, and sudden drop in blood pressure, leading to collapse.
6. Acupoint shot can cause muscle atrophy, joint dysfunction and so on.
7. metamizole can also cause drowsiness, burnout, headache, nausea, vomiting, dry out mouth, urinary discoloration, bronchospasm, pemphigus vulgaris and other adverse reactions.
